Immune function
Multiple sclerosis.
This set of epidemiological studies aims to examine the effect of environmental factors on the development of multiple sclerosis. We have a particular interest in vitamin D, sun exposure, viral infections, smoking, occupational exposures, and how associations with each of these factors could be modified by genetic factors.
Ausimmune Study
A multi-centre case control study in Brisbane, Newcastle, Geelong and the Western Districts of Victoria, and Tasmania) recruiting individuals with a first clinical diagnosis of central nervous system demyelination and age and sex-matched controls. We recently showed that higher sun exposure and vitamin D status independently decreased the risk of being a case.
Researchers: A/Prof Robyn Lucas, Dr Ann Hughes, Prof Tony McMichael, Dr Keith Dear
AusLong Study
A cohort study following the Ausimmune case group to 5 years from initial study interview, to examine risk factors for progression from initial symptoms to diagnosed MS.
Researchers: A/Prof Robyn Lucas
AusUVI study
A two-centre clinical trial of the effect of natural levels of solar ultraviolet radiation exposure on the immune response to vaccination with a novel antigen. Ultraviolet radiation exposure is being measured with the use of innovative digital dosimeters worn on the wrist. The AusUVI study is run by Dr Ashwin Swaminathan and is currently recruiting volunteer participants aged 18-40 years living in
